Guo Chun. STUDY ON MECHANICAL REGULATION OF BONE CELLS[J]. Advances in Mechanics, 2009, 39(2): 228-235. doi: 10.6052/1000-0992-2009-2-J2008-020
Citation: Guo Chun. STUDY ON MECHANICAL REGULATION OF BONE CELLS[J]. Advances in Mechanics, 2009, 39(2): 228-235. doi: 10.6052/1000-0992-2009-2-J2008-020

STUDY ON MECHANICAL REGULATION OF BONE CELLS

doi: 10.6052/1000-0992-2009-2-J2008-020
  • Received Date: 2008-02-18
  • Rev Recd Date: 2008-07-28
  • Publish Date: 2009-03-25
  • It is widely believedthat mechanical environment plays a critical role in theformation, proliferation and maturation of bone cells. Osteocytesas mechanosensors have the ability to transmit mechanical signalsto effector cells, osteoblasts and osteoclasts. Bone mechanicalintegrity is maintained by a dynamic balance between boneresorption by osteoclasts and bone formation by osteoblasts.However, the mechanisms of cellular mechanical regulations in bonecells are not clearly understood. In this paper, several relevantstudies on the cellular mechanobiology and intercellularmechanical regulation in bone are reviewed and discussed. Based ona brief introduction of the biological properties of osteoblasts,osteocytes and osteoclasts, the principle of mechanical regulationin bone remodeling is presented, and the resent progresses in thecellular mechanobiology and intercellular mechanical regulation ofbone cells are elaborated. Finally, the future trend of researchon three-dimensional web of mechanical regulation in bone cells isprospected.

     

  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2378) PDF downloads(1438) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return