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GE Lin. AFM force spectroscopy and its applications on micro biomechanics[J]. Advances in Mechanics, 2018, 48(1): 1811. doi: 10.6052/1000-0992-17-011
Citation: GE Lin. AFM force spectroscopy and its applications on micro biomechanics[J]. Advances in Mechanics, 2018, 48(1): 1811. doi: 10.6052/1000-0992-17-011
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AFM force spectroscopy and its applications on micro biomechanics

doi: 10.6052/1000-0992-17-011

  • NT-MDT, China office, Beijing 100031, China

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  • Corresponding author: GE Lin
  • Received Date: 2017-05-18
  • Publish Date: 2018-02-08
    Abstract
  • Atomic force microscopy (AFM) based force spectroscopy is a high-sensitive mechanical detection method. With unprecedented accuracy, this method enables the characterization of a wide range of biological and synthetic bio-interfaces, ranging from tissues, cells, membranes, proteins, nucleic acids to functional materials. Besides the possibility of high resolution imaging of biological samples from the cellular level to the molecular level, AFM-based force spectroscopy allows their mechanical, chemical, conductive or electrostatic, and biological properties to be probed, and helps addressing fundamental challenges that cannot be addressed with other techniques. In this review, we summarize basic and advanced force spectroscopy approaches in micro biomechanics and evaluate their unique advantages and limitations.

     

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