The mechanical problems in tumor and tumor microenvironment

SHI Xinghua; ZHANG Luyao; LI Bo; FENG Xiqiao

doi:10.6052/1000-0992-16-039

Volume 48 Issue 1

Feb. 2018

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SHI Xinghua, ZHANG Luyao, LI Bo, FENG Xiqiao. The mechanical problems in tumor and tumor microenvironment[J]. Advances in Mechanics, 2018, 48(1): 1808. doi: 10.6052/1000-0992-16-039

Citation:

SHI Xinghua, ZHANG Luyao, LI Bo, FENG Xiqiao. The mechanical problems in tumor and tumor microenvironment[J]. Advances in Mechanics, 2018, 48(1): 1808. doi: 10.6052/1000-0992-16-039

SHI Xinghua, ZHANG Luyao, LI Bo, FENG Xiqiao. The mechanical problems in tumor and tumor microenvironment[J]. Advances in Mechanics, 2018, 48(1): 1808. doi: 10.6052/1000-0992-16-039

Citation:

SHI Xinghua, ZHANG Luyao, LI Bo, FENG Xiqiao. The mechanical problems in tumor and tumor microenvironment[J]. Advances in Mechanics, 2018, 48(1): 1808. doi: 10.6052/1000-0992-16-039

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The mechanical problems in tumor and tumor microenvironment

doi: 10.6052/1000-0992-16-039

SHI Xinghua^{1,2,ɛ
,
,},
ZHANG Luyao^1,2,3,
LI Bo⁴,
FENG Xiqiao^{4,’
,
,}

1 CAS Key Laboratory for Nanosystem and Hierarchy Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, China
2 University of Chinese Academy of Science, Beijing 100049, China
3 LNM, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China
4 Institute of Biomechanics and Medical Engineering, AML, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China

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Author Bio:
^’ E-mail:fengxq@tsinghua.edu.cn
^ɛ E-mail:shixh@nanoctr.cn
Corresponding author: SHI Xinghua; FENG Xiqiao
Received Date: 2016-11-08
Publish Date: 2018-02-08

Abstract

Abstract

Tumor microenvironment contains tumor cells, stromal cells and extracellular matrix, which plays an important role in tumor growth and development. The tumor microenvironment has its unique structural features. Physical forces in tumors can change the tumor microenvironment, disable the blood and lymphatic vessels, result in the abnormal metabolism, compress the interstitial structure, hinder the delivery of drugs, and induce stromal cells to change their behavior and promote tumor metastasis. So the forces in tumor have attracted increasing attention. In this review, we summarize the advances of mechanics problems in tumor and its microenvironments. We discuss the causes of solid stress, drug delivery and tumor metastasis. Also we introduce several strategies to restore the tumor microenvironments and their effects on tumor therapy.
- tumor microenvironment,
- biomechanics,
- solid stress,
- drug delivery,
- metastasis

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References(295)

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