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摘要:
造血系统是人体中复杂的调控系统, 包括复杂的造血器官和各种血液细胞的增生、分化、成熟、死亡等过程和对这些过程的反馈控制, 是典型的非线性时滞动力系统. 血细胞生成过程的失调可以引起很多动态血液病. 血细胞生成的系统动力学研究对于人们了解和治疗这些血液病有重大意义. 本文从造血系统的基本知识、常见动态血液病的临床表现及其动力学特征、理论模型的建立和对模型的动力学分析等方面综述血细胞生成的系统动力学研究进展.
Abstract:Hematopoiesis is a complex regulation system in human body, which is a typical nonlinear delay dynamical system, including proliferation, maturation and apoptosis of different types of blood cells, and feedback controls to these processes. Deregulations in the hematopoiesis can induce many dynamical blood diseases. Studies of hematological dynamics are important for understanding and treating these diseases. This paper surveys recent progresses in hematological dynamics studies, including basic knowledge of the hematopoiesis, clinical manifestation of dynamical blood disease and their dynamical characteristics, theoretical models and dynamical analysis.
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Key words:
- Hematopoiesis /
- dynamical blood disease /
- delay dynamics /
- bifurcation /
- control
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