Abstract: Repetitive loading on bones, as in all syntheticstructural materials, causes fatigue failure. Recently, a great progress has been made in research on bone fatigue damage. Investigations in the area of fatigue in bone are reviewed with special emphasis on the topics of common interest. These include the nature of fatigue damage in bone, modeling of bone damage evolution in terms of microcracks for bone fatigue, and experimental quantification of bone fatigue behavior. Further researches required to better understand fatigue damage, repair, and remodeling behaviors in bone are identified.