Abstract: The structure and the function of bones are dependent to a large extent on its mechanical environment, and this point of view has been widely accepted. Since Wolff presented his famous Law of Bone Transformation, the relationship between the bone formation and the mechanical loading has become an important question of biomechanics. Numerous animal experiments demonstrated a clear linkage between them. However, the mechanocytobiological mechanisms were poorly understood. The loading studies on in vitro cul...