Abstract: Erythrocyte aggregation is a kind of non-specific cell-to-cell adhesion.Macroscopically,it is thermodynamical process bywhich 3-Dnetwork structure is gradually develpoed from disseparated single cells.And microscopically,it is a kind of macromolecule-involiving veak contaction between cell membranes.Models were reviewed on the biomechanism of aggregate formation.