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基于先进生物材料的心肌细胞力--电微环境体外构建

徐峰 张晓慧 鲍雪娇 赵国旭 刘付生 黄国友 李昱辉 卢天健

徐峰, 张晓慧, 鲍雪娇, 赵国旭, 刘付生, 黄国友, 李昱辉, 卢天健. 基于先进生物材料的心肌细胞力--电微环境体外构建[J]. 力学进展, 2018, 48(1): 1807. doi: 10.6052/1000-0992-17-014
引用本文: 徐峰, 张晓慧, 鲍雪娇, 赵国旭, 刘付生, 黄国友, 李昱辉, 卢天健. 基于先进生物材料的心肌细胞力--电微环境体外构建[J]. 力学进展, 2018, 48(1): 1807. doi: 10.6052/1000-0992-17-014
XU Feng, ZHANG Xiaohui, BAO Xuejiao, ZHAO Guoxu, LIU Fusheng, HUANG Guoyou, LI Yuhui, LU Tianjian. Engineering mechanical-electrical cell microenvironment in myocardium using advanced biomaterials[J]. Advances in Mechanics, 2018, 48(1): 1807. doi: 10.6052/1000-0992-17-014
Citation: XU Feng, ZHANG Xiaohui, BAO Xuejiao, ZHAO Guoxu, LIU Fusheng, HUANG Guoyou, LI Yuhui, LU Tianjian. Engineering mechanical-electrical cell microenvironment in myocardium using advanced biomaterials[J]. Advances in Mechanics, 2018, 48(1): 1807. doi: 10.6052/1000-0992-17-014

基于先进生物材料的心肌细胞力--电微环境体外构建

doi: 10.6052/1000-0992-17-014
基金项目: 国家自然科学基金(81401270, 11372243, 11522219, 11532009)、陕西省自然科学基础研究计划(2015JM3108)、徐峰和张晓慧的青年千人计划项目资助
详细信息
    作者简介:

    null

    作者简介:
    徐峰, 2008年取得剑桥大学工程学博士学位, 2008---2011年在哈佛医学院/哈佛大学--麻省理工学院健康科学与技术研究中心任博士后.2011年回国, 现任西安交通大学教授、生命学院副院长, 同卢天健教授共同建立 "仿生工程与生物力学研究中心", 并担任主任.在课题开展中遵循"力学基础理论--生物技术研发--应用推广"的学术思路, 通过理解和探索人体组织/细胞的力学行为和力学环境, 将固体力学和流体力学与工程学、生物医学等领域进行交叉融合, 开展了生物组织热--力--电耦合学、细胞热--力--电微环境工程、基于生物微流体力学的即时诊断技术的研究.科研成果包括中英文专著和教材5本; 作为第一/通讯作者发表150余篇论文; 发明专利20余项; 在生物热--力耦合学方面的工作获得国家自然科学奖二等奖(第二完成人)、教育部科学技术奖一等奖(第二完成人).
    张晓慧, 2009年获得美国塔夫茨大学生物技术博士学位, 2009---2013年在哈佛医学院/哈佛大学--麻省理工学院健康科学与技术研究中心任博士后, 2013年全职回国, 现任西安交通大学教授.致力于新型生物材料的开发与应用、工程化组织器官及疾病模型的体外构建、生殖医学工程以及细胞冷冻保存等生物医学领域中的应用研究.2013年入选中组部"青年千人计划". 迄今已在 Advanced Functional Materials. Biomaterials等国际知名学术期刊发表SCI 论文40 余篇, 总引用次数超过 2200 次, H 因子24. 另申报发明专利7 项 (国际 2 项, 美国 2 项, 欧洲 1 项, 日本 1 项, 中国 1 项), 其中5 项为第一发明人. 担任SCI 期刊 Nanobiomedicine 的编委, 应邀担任期刊{\it ASME Journal of Nanotechnology in Engineering and Medicine 专刊副主编, 2014年国际组织工程与再生医学学会亚太年会(TERMIS-AP 2014) 的分会主席.

    通讯作者:

    张晓慧

  • 中图分类号: Q27,R329,2+7;

Engineering mechanical-electrical cell microenvironment in myocardium using advanced biomaterials

More Information
    Author Bio:

    ɛ E-mail:xiaohuizhang@mail.xjtu.edu.cn

    Corresponding author: ZHANG Xiaohui
  • 摘要: 心血管疾病是当前全球范围内导致人类死亡的首要原因, 心肌组织工程的发展为心血管疾病的治疗, 尤其是心肌组织再生修复提供了最有潜力的解决方案.心血管疾病的发生发展与细胞力--电微环境的变化密切相关. 近十几年, 随着先进生物材料和微纳生物制造技术的发展, 越来越多的研究表明, 细胞力--电微环境的调控对工程化心肌组织的成熟和功能化以及心肌组织再生修复具有重要意义. 本文首先阐明了在体心肌细胞所处力学微环境的生物学基础以及电信号的传导过程, 包括正常和疾病状态下心肌细胞所处的力--电微环境.其次调研了用于心肌组织工程的先进生物材料的研究现状.最后总结用于基底硬度与应力应变细胞微环境以及细胞电学微环境的构建和调控, 以及细胞对力--电微环境的生物学响应.%

     

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  • 收稿日期:  2017-07-04
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