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软骨组织工程构建中的生物力学

张春秋 李可 高丽兰 张西正

张春秋, 李可, 高丽兰, 张西正. 软骨组织工程构建中的生物力学[J]. 力学进展, 2018, 48(1): 1809. doi: 10.6052/1000-0992-17-007
引用本文: 张春秋, 李可, 高丽兰, 张西正. 软骨组织工程构建中的生物力学[J]. 力学进展, 2018, 48(1): 1809. doi: 10.6052/1000-0992-17-007
ZHANG Chunqiu, LI Ke, GAO Lilan, ZHANG Xizheng. Biomechanics in cartilage tissue engineering[J]. Advances in Mechanics, 2018, 48(1): 1809. doi: 10.6052/1000-0992-17-007
Citation: ZHANG Chunqiu, LI Ke, GAO Lilan, ZHANG Xizheng. Biomechanics in cartilage tissue engineering[J]. Advances in Mechanics, 2018, 48(1): 1809. doi: 10.6052/1000-0992-17-007

软骨组织工程构建中的生物力学

doi: 10.6052/1000-0992-17-007
基金项目: 国家自然科学基金重点项目(11432016), 国家自然科学基金(11672208, 11572222, 11402171, 11402172)资助
详细信息
    作者简介:

    null

    作者简介:张春秋, 男, 天津理工大学机械工程学院教授、博士生导师; 2003年获得吉林大学固体力学博士学位, 2006年于解放军军事医学科学院生物学博士后出站, 2009年于北京航空航天大学生物医学工程博士后出站; 2013年在布朗大学做访问学者. 任中国力学学会生物力学专业委员会委员, 天津市力学学会理事, 天津市力学学会生物力学专业委员会副主任委员; 天津市中青年骨干创新人才, 天津市高校学科领军人才.主要从事生物力学、组织工程生物反应器、固体力学数值方法和应用的研究, 研究方向主要为骨、软骨生物力学; 近年来承担国家级、省部级基金和横向课题10余项, 其中主持国家自然科学基金4项; 在国内外刊物发表学术论文100余篇, 其中SCI、EI收录30余篇; 授权发明专利16项; 2014年获中国人民武装警察部队科学技术进步二等奖.

    通讯作者:

    张春秋

  • 中图分类号: R318.01;

Biomechanics in cartilage tissue engineering

More Information
    Author Bio:

    ɛ E-mail:zhang chunqiu@126.com

    Corresponding author: ZHANG Chunqiu
  • 摘要: 关节软骨是关节表面具有弹性的承重组织, 其结构复杂, 由固体相和液体相组成. 固体相包括胶原纤维、蛋白多糖等, 属纤维增强型复合结构; 液体相包括水、电解质等.关节软骨提供了一个低磨损和低摩擦的光滑界面, 起缓冲振动和传递载荷等支撑作用. 由于膝关节承受的运动量大、应力高, 关节软骨损伤在临床上较为常见. 但软骨内没有血管, 代谢缓慢, 其损伤后难以实现自我修复. 组织工程从理论上建立了一种治疗软骨缺损的理想方法, 但尚未成为临床上常规的治疗选择. 如何获得结构和功能相匹配, 同时适用于临床治疗的工程软骨, 至今仍是亟需解决的问题.在体外构建功能化工程软骨, 关键在于运用生物反应器对组织施加合适的力学载荷: 首先保证工程软骨复合体内信号分子、营养和废物的有效运输; 其次对支架内种子细胞产生特定的力学刺激; 同时促进细胞外基质结构与功能的适应性发展.本文对力学载荷在软骨组织工程构建中的应用进展加以综述: 按照作用于组织层面的力学载荷传递所需的介质属性, 将其分为液体介导、固体介导和其他媒质介导三种类型, 重点关注不同载荷对工程软骨功能化构建的作用和效果; 分析讨论软骨组织工程构建中存在的关键生物力学问题; 总结和展望软骨组织工程未来的发展趋势.软骨组织工程体外培养需要考虑力学载荷和生化刺激的耦合作用; 在合适的生化条件下进行滚动、滑动和压缩复合加载, 将有利于工程软骨的体外功能化构建.

     

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  • 收稿日期:  2017-04-01
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