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肿瘤及其微环境的力学问题

施兴华 张路姚 李博 冯西桥

施兴华, 张路姚, 李博, 冯西桥. 肿瘤及其微环境的力学问题[J]. 力学进展, 2018, 48(1): 1808. doi: 10.6052/1000-0992-16-039
引用本文: 施兴华, 张路姚, 李博, 冯西桥. 肿瘤及其微环境的力学问题[J]. 力学进展, 2018, 48(1): 1808. doi: 10.6052/1000-0992-16-039
SHI Xinghua, ZHANG Luyao, LI Bo, FENG Xiqiao. The mechanical problems in tumor and tumor microenvironment[J]. Advances in Mechanics, 2018, 48(1): 1808. doi: 10.6052/1000-0992-16-039
Citation: SHI Xinghua, ZHANG Luyao, LI Bo, FENG Xiqiao. The mechanical problems in tumor and tumor microenvironment[J]. Advances in Mechanics, 2018, 48(1): 1808. doi: 10.6052/1000-0992-16-039

肿瘤及其微环境的力学问题

doi: 10.6052/1000-0992-16-039
基金项目: 国家自然科学基金项目资助 (11422215, 11272327, 11672079, 11432008,11620101001)
详细信息
    作者简介:

    null

    作者简介:
    施兴华, 国家纳米科学中心研究员, 博士生导师, 中国科学院大学岗位教授. 2001年本科毕业于北京大学力学与工程科学系, 2004年获中国科学院力学研究所硕士学位, 2010年获美国布朗大学博士学位, 2010年12月在中国科学院力学研究所任副研究员, 2016年3月加入国家纳米科学中心工作.近期主要从事力学与纳米材料、生物科学交叉领域的研究工作.2014年获基金委优秀青年基金.
    李博, 清华大学工程力学系副教授, 博士生导师.2004年、2007年先后于湖南大学工程力学系获学士、硕士学位, 2011年获清华大学工程力学系博士学位.2011年9月至2014年8月在美国约翰\(\cdot\)霍普金斯大学从事博士后研究工作.2015年5月加入清华大学工程力学系工作.主要研究方向为生物软组织力学、细胞力学.曾获2013年全国优秀博士学位论文奖, 2015年入选中组部"青年千人计划".
    冯西桥, 1968年生.现任清华大学工程力学系主任、生物力学与医学工程研究所所长、长江学者特聘教授.1990年7月、1991年7月和1995年3月先后在清华大学工程力学系获学士、硕士和博士学位.1997年6月清华大学核研院博士后出站. 之后获洪堡奖学金, 在德国Darmstadt工业大学和荷兰Delft工业大学任洪堡研究员.1999年回国, 在清华大学工程力学系任副教授, 2001年任教授.其主要研究方向是生物材料力学、损伤与断裂力学, 发表SCI论文约200篇、专著3部.曾获中国青年科技奖、国家杰出青年科学基金、全国优秀博士学位论文奖及指导教师奖等奖励.

    通讯作者:

    施兴华

    冯西桥

  • 中图分类号: Q66;

The mechanical problems in tumor and tumor microenvironment

More Information
    Author Bio:

    E-mail:fengxq@tsinghua.edu.cn
    ɛ E-mail:shixh@nanoctr.cn

    Corresponding author: SHI Xinghua; FENG Xiqiao
  • 摘要: 肿瘤微环境包括肿瘤细胞、间质细胞、细胞外基质等.其在肿瘤的生长和发展过程中起着关键作用.肿瘤的微环境与正常组织的微环境有着显著的不同.肿瘤中的压应力对微环境有着多方面的影响, 例如, 可调控血管与淋巴管的功能, 造成代谢异常和间质高压, 压缩间隙基质, 增大药物输运的困难, 促进间质细胞变异并诱导肿瘤细胞转移. 因此, 肿瘤中的力学因素引起了广泛关注.本文总结了肿瘤及其微环境力学问题的研究进展, 讨论了肿瘤微环境中应力产生、药物输运、肿瘤转移等问题, 介绍了肿瘤微环境正常化的策略及其对肿瘤治疗的意义.

     

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  • 收稿日期:  2016-11-08
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