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Lü Dongyuan, ZHOU Lüwen, LONG Mian. Biomechanics of stem cells[J]. Advances in Mechanics, 2017, 47(1): 534-585. doi: 10.6052/1000-0992-16-041
Citation: Lü Dongyuan, ZHOU Lüwen, LONG Mian. Biomechanics of stem cells[J]. Advances in Mechanics, 2017, 47(1): 534-585. doi: 10.6052/1000-0992-16-041
shu

Biomechanics of stem cells

doi: 10.6052/1000-0992-16-041

  • Key Laboratory of Microgravity (National Microgravity Laboratory) and Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China

  • Received Date: 2016-11-15
    Available Online: 2017-01-24
  • Publish Date: 2017-02-24
    Abstract
  • As an important branch of biomechanics, stem cell biomechanics has made great progress in mechano-biological, mechano-chemical coupling, and other related felds in recent years. It has become one of the most active felds in biomechanics and biomedical engineering, and made signifcant impacts on the areas of stem cell biology, tissue repair, regenerative medicine, and so on. Stem cells have unique mechanical properties, which can sense, transmit, transduce and respond to changes in physiological and mechanical microen-vironment, thus regulating the function of stem cell growth and differentiation, showing a typical mechano-biological coupling characteristics. This paper reviews the mechanical properties of stem cells and cell mechanics models, the effects of in vivo mechanical mi-croenvironment on stem cell growth and differentiation, and the responses of stem cells to external mechanical stimuli.

     

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