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力学进展 ›› 2018, Vol. 48 ›› Issue (1): 201807-201807.doi: 10.6052/1000-0992-17-014

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基于先进生物材料的心肌细胞力--电微环境体外构建

徐峰1, 2, 张晓慧1, 2, †, 鲍雪娇1, 2, 赵国旭1, 2, 刘付生2, 3, 黄国友1, 2, 李昱辉1, 2, 卢天健4   

  1. 1 西安交通大学生命科学与技术学院, 生物信息工程教育部重点实验室, 西安 710049;
    2 西安交通大学仿生工程与生物力学中心, 西安 710049;
    3 西安交通大学航空航天学院, 振动与强度国家重点实验室, 西安710049;
    4 西安交通大学多功能材料与结构教育部重点实验室, 西安 710049
  • 收稿日期:2017-07-04 出版日期:2018-03-25 发布日期:2018-01-22
  • 作者简介:徐峰,2008年取得剑桥大学工程学博士学位,2008---2011年在哈佛医学院/哈佛大学--麻省理工学院健康科学与技术研究中心任博士后.
  • 基金资助:

    国家自然科学基金(81401270, 11372243, 11522219, 11532009)、陕西省自然科学基础研究计划(2015JM3108)、徐峰和张晓慧的青年千人计划项目资助

Engineering mechanical-electrical cell microenvironment in myocardium using advanced biomaterials

XU Feng1, 2, ZHANG Xiaohui1, 2, †, BAO Xuejiao1, 2, ZHAO Guoxu1, 2, LIU Fusheng2, 3, HUANG Guoyou1, 2, LI Yuhui1, 2, LU Tianjian4   

  1. 1 The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China;
    2 Bioinspired Engineering and Biomechanics Center (BEBC),Xi'an Jiaotong University, Xi'an 710049, China;
    3 State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace, Xi'an Jiaotong University, Xi'an 710049, China;
    4 Moe Key Laboratory for Multifunction Materials and Structure,Xi'an Jiaotong University, Xi'an 710049, China;
  • Received:2017-07-04 Online:2018-03-25 Published:2018-01-22

摘要:

心血管疾病是当前全球范围内导致人类死亡的首要原因, 心肌组织工程的发展为心血管疾病的治疗, 尤其是心肌组织再生修复提供了最有潜力的解决方案.心血管疾病的发生发展与细胞力--电微环境的变化密切相关. 近十几年, 随着先进生物材料和微纳生物制造技术的发展, 越来越多的研究表明, 细胞力--电微环境的调控对工程化心肌组织的成熟和功能化以及心肌组织再生修复具有重要意义. 本文首先阐明了在体心肌细胞所处力学微环境的生物学基础以及电信号的传导过程, 包括正常和疾病状态下心肌细胞所处的力--电微环境.其次调研了用于心肌组织工程的先进生物材料的研究现状.最后总结用于基底硬度与应力应变细胞微环境以及细胞电学微环境的构建和调控, 以及细胞对力--电微环境的生物学响应.%

关键词: 细胞力学微环境, 细胞电学微环境, 心肌组织工程, 生物材料

Abstract:

Cardiovascular diseases remain the leading cause of human death worldwide. The development of cardiac tissue engineering has provided a most potential strategy for the treatment of cardiovascular disease through regenerating functional cardiac tissues and restoring dysfunctional myocardium. The occurrence and progress of cardiovascular diseases are closely related to the changes of mechanical and electrical cell microenvironment in native myocardium. In the last decades, with the advances in biomaterials and micro- and nano-fabrication techniques, increasing evidence has demonstrated that the biomimicking of mechanical-electrical cell microenvironment is important for the maturation and functionalization of engineered cardiac tissues for the purpose of myocardium restoration. In this review, we firstly elucidated the biological basis of mechanical properties and electrical signal transmission in native myocardium, including the mechanical and electrical microenvironment in physiological and pathological conditions. Then, we reviewed the current research progress of advanced biomaterials for cardiac tissue engineering applications. Finally, we summarized the development and manipulation of mechanical and electrical microenvironment using advanced biomaterials, and the biological responses of cardiomyocytes and cardiac tissues to the biomimicking mechanical-electrical microenvironment.

Key words: mechanical microenvironment, electrical microenvironment, cardiac tissue engineering, biomaterial

中图分类号: 

  • Q27