THE MECHANICS OF CYTOKINESIS AND MOLECULAR MECHANISM
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摘要: 胞质分裂通过一系列的形态学变化使母细胞一分为二生成两个子细胞,几乎整个胞质分裂过程都伴随着力学现象.形成刚度或黏弹性互不相同的区域对细胞形态的改变至关重要,特殊肌动蛋白与交联蛋白是导致细胞局部刚度改变的重要因素.因此有必要深入理解细胞如何变形、以及促进细胞变形的材料特性及其分子生物学基础.本文将针对细胞的力学特性、胞质分裂中的力学现象以及分子生物学基础进行讨论.
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关键词:
- 胞质分裂, 力学,分子生物学
Abstract: Cytokinesis, themechanical separation of a mother cell into two daughter cells,occurs through a series of stereotypical shape changes.Cytokinesis is accompanied by mechanical phenomena through almostevery level. The formation of cortical subdomains with differentstiffness and viscoelasticity is critical for the resulting cellshape change. The recruitment of specific actin cross-linkingproteins is important for the local change of the stiffness. It isessential to understand fully the process of cells changing theirshapes, the cellular material properties achieving successfulcytokinesis, and the basis of molecular biology of cytokinesis. Inthis review, the mechanical properties of cells, the mechanics ofcytokinesis, and the molecular biology basis of cytokinesis arediscussed.-
Key words:
- cytokinesis, mechanics, molecularbiology
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