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力学进展 ›› 2017, Vol. 47 ›› Issue (1): 201715-201715.doi: 10.6052/1000-0992-16-041

• 综述评论 • 上一篇    

干细胞的生物力学研究

吕东媛, 周吕文, 龙勉   

  1. 中国科学院力学研究所微重力重点实验室/工程化构建与力学生物学北京市重点实验室, 北京 100190
  • 收稿日期:2016-11-15 出版日期:2017-01-01 发布日期:2017-01-23
  • 通讯作者: 龙勉,工学博士,中科院力学所研究员,博士生导师.1995年晋升为教授,2000年入选中科院"百人计划",2002年获国家杰出青年基金,2004年入选"新世纪百千万人才工程国家级人选".先后任世界生物力学理事会(WCB)执委、国际生物流变学学会(ISB)理事、世界华人生物医学工程协会(WACBE)理事、中国力学学会副理事长等,担任Cell. Mol. Bioengi.,Biophys. Rep.副主编及相关杂志编委.研究兴趣为蛋白质间相互作用与组装动力学、细胞{亚细胞力学{生物学耦合、空间细胞{分子生物力学工程.在Nature,Biomaterials,J Immunol.等杂志发表学术论文124篇.获教育部首届青年教师奖、中国力学学会青年科技奖等.E-mail:mlong@imech.ac.cn E-mail:mlong@imech.ac.cn

Biomechanics of stem cells

LÜ Dongyuan, ZHOU Lüwen, LONG Mian   

  1. Key Laboratory of Microgravity(National Microgravity Laboratory) and Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China
  • Received:2016-11-15 Online:2017-01-01 Published:2017-01-23

摘要:

干细胞生物力学作为生物力学的重要分支和前沿学科,近年来在力学-生物学、力学-化学耦合等方面取得了重大进展,已成为生物力学乃至生物医学工程最活跃的领域之一,并对发生物学、干细胞生物学、组织修复、再生医学等相关领域产生重要影响.干细胞具有独特的力学性质,可感知、传递、转导和响应生理力学微环境的改变,从而调控干细胞的生长、分化等功能,体现出典型的力学-生物学耦合特征.本文将对干细胞的力学性质与细胞力学模型、在体力学环境对干细胞生长和分化的影响、干细胞对外界力学刺激的响应等方面加以综述.

关键词:

干细胞|生物力学|力学-生物学耦合|力学微环境|信号传递与转导

Abstract:

Stem cell biomechanics is an emerging fleld in biomechanics. It has achieved great progress in the past decades for stem cell mechano-biological and mechano-chemical coupling and also made signiflcant impacts on the related flelds of developmental biology, stem cell biology, tissue repair, and regenerative medicine. Stem cells have the specialized mechanical properties. They can sense, trasmit, transduce, and response to the alterations of physiologically mechanical microenvironment and in turn manipulate their functions in cell growth and difierentiation, presenting typical characteristics of mechano-biological coupling. This review mainly discusses their mechanical properties and modeling, the impacts of in vivo mechanical microenvironment on stem cell growth and difierentiation, and the responses of stem cells to external mechanical stimuli.

Key words:

stem cell|biomechanics|mechano-biological coupling|mechanical microenvironment|signal transmission and transduction

中图分类号: 

  • R318.01