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干细胞的生物力学研究

吕东媛 周吕文 龙勉

吕东媛, 周吕文, 龙勉. 干细胞的生物力学研究[J]. 力学进展, 2017, 47(1): 534-585. doi: 10.6052/1000-0992-16-041
引用本文: 吕东媛, 周吕文, 龙勉. 干细胞的生物力学研究[J]. 力学进展, 2017, 47(1): 534-585. doi: 10.6052/1000-0992-16-041
Lü Dongyuan, ZHOU Lüwen, LONG Mian. Biomechanics of stem cells[J]. Advances in Mechanics, 2017, 47(1): 534-585. doi: 10.6052/1000-0992-16-041
Citation: Lü Dongyuan, ZHOU Lüwen, LONG Mian. Biomechanics of stem cells[J]. Advances in Mechanics, 2017, 47(1): 534-585. doi: 10.6052/1000-0992-16-041

干细胞的生物力学研究

doi: 10.6052/1000-0992-16-041
详细信息
    作者简介:

    龙勉, 工学博士, 中科院力学所研究员, 博士生导师. 1995 年晋升为教授,2000 年入选中科院"百人计划", 2002 年获国家杰出青年基金, 2004 年入选"新世纪百千万人才工程国家级人选". 先后任世界生物力学理事会(WCB) 执委、国际生物流变学学会(ISB) 理事、世界华人生物医学工程协会(WACBE) 理事、中国力学学会副理事长等, 担任C ell. Mol. Bioengi.,Biophys. Rep. 副主编及相关杂志编委. 研究兴趣为蛋白质间相互作用与组装动力学、细胞-亚细胞力学-生物学耦合、空间细胞-分子生物力学工程. 在Nature, Biomaterials, J Immunol. 等杂志发表学术论文124篇. 获教育部首届青年教师奖、中国力学学会青年科技奖等. mlong@imech.ac.cn

  • 中图分类号: R 318.01

Biomechanics of stem cells

  • 摘要: 干细胞生物力学作为生物力学的重要分支和前沿学科, 近年来在力学-生物学、力学-化学耦合等方面取得了重大进展, 已成为生物力学乃至生物医学工程最活跃的领域之一, 并对发育生物学、干细胞生物学、组织修复、再生医学等相关领域产生重要影响. 干细胞具有独特的力学性质, 可感知、传递、转导和响应生理力学微环境的改变, 从而调控干细胞的生长、分化等功能, 体现出典型的力学-生物学耦合特征. 本文将对干细胞的力学性质与细胞力学模型、在体力学环境对干细胞生长和分化的影响、干细胞对外界力学刺激的响应等方面加以综述.

     

  • 图  1  典型的4种连续介质细胞模型.(a)线弹性固体模型(b)黏弹性固体模型(c)牛顿液滴模型,(d)复合液滴模型

    图  2  典型的3种细胞结构模型.(a)开孔泡沫模型,(b)索网模型(c)六杆张力整合模型

    图  3  组织微观力学影响干细胞分化并与细胞核内富含的骨架蛋白lamins相关( Swift et al. 2013)

    图  4  线粒体动力学通过调控核转录程序影响干细胞命运( Khacho et al. 2016)

    图  5  组织形态建成中的力学因素( Patwari & Lee 2008)

    图  6  干细胞"壁龛"中的力学作用模式( Conway & Schaffer 2012)

    图  7  硬度范围与相应的组织类型( Buxboim et al. 2010)

    图  8  基底硬度耦合拓扑结构对MSC的影响.(a)MSC在不同基底上的形态、细胞骨架及黏附斑蛋白的表达,(b)结构模式示意图

    图  9  不同基底硬度耦合拓扑结构基底对胚胎干细胞干性的影响(Lü et al. 2014)

    图  10  细胞力学信号转导的媒介( Ingber 2006)

    图  11  黏着斑复合物结构示意图( Mitra et al. 2005)

    图  12  力学组学概念示意图

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  • 收稿日期:  2016-11-15
  • 网络出版日期:  2017-01-24
  • 刊出日期:  2017-02-24

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